Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis

Negation: Pregnenolone and progesterone deficiency does not cause memory loss, destabilization of nerve cells, failure of myelin formation, or excess cortisol synthesis 0 0 0

1 Argument

0 Citations

1 Consequence

2 Mentions

Arguments

Argument #c25abf36 1 0 2

If it is true that...

Estrogen and calcium depolymerize microtubules 1 0 2

and

Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2

Then it must be true that...

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2

Opposing Arguments

No opposing arguments found

Citations

No citations found

Consequences

Argument #ed860ec9 1 0 2

If it is true that...

Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted 1 0 2

and

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs 1 0 2

Mentions

Ray Peat/The problem of Alzheimer's disease as a clue to immortality

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Related Propositions

The absence of bright light can create a progesterone deficiency and leave estrogen and prolactin unopposed 1 0 2 Progesterone and pregnenolone, by reducing the stress reactions, should be helpful in the eye diseases of infancy and old age, as they are in the respiratory distress syndromes 1 0 1 Cholesterol, pregnenolone, and progesterone are the main long-range defenses in the human body 1 0 2 Progesterone is a nerve growth factor, produced by glial cells 1 0 2 Stress is normally balanced by increased synthesis of pregnenolone, which improves the ability to cope with stress 1 0 2 When pregnenolone is inadequate, cortisol is over-produced 1 0 2 When progesterone is deficient, estrogen's effect is largely unopposed 1 0 2 The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1 Increased cortisol and DHEA are associated with Alzheimer's disease 1 0 1 Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency 1 0 2