Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted

Negation: Transthyretin and apo E do not accumulate unused, nor deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted 0 0 0

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Argument #ed860ec9 1 0 2

If it is true that...

Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted 1 0 2

and

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs 1 0 2

Mentions

Ray Peat/The problem of Alzheimer's disease as a clue to immortality

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Related Propositions

Polyunsaturated fats that accumulate in the brain and retina damage mitochondria 1 0 2 Endotoxin impairs mitochondria, increases estrogen levels, causes Kupffer cells in the liver to produce more tumor necrosis factor 1 0 2 Endotoxemia may be a factor in nerve degeneration only during adult life, but it is sometimes present during pregnancy 1 0 2 Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age 1 0 2 The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1 Abnormally phosphorylated (tau) proteins are associated with Alzheimer's disease 1 0 1 Apoe, in cytoplasm, is involved in cholesterol delivery for pregnenolone synthesis 1 0 1 Estrogen and calcium depolymerize microtubules 1 0 2 Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2 Hypothyroidism, estrogen excess, free unsaturated fats cause increased vascular permeability and brain edema, protein leakage, and alteration of the matrix 1 0 2