Transthyretin and apo E do not accumulate unused, nor deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted
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Polyunsaturated fats that accumulate in the brain and retina damage mitochondria 1 0 2Endotoxemia may be a factor in nerve degeneration only during adult life, but it is sometimes present during pregnancy 1 0 2Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age 1 0 2The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1Abnormally phosphorylated (tau) proteins are associated with Alzheimer's disease 1 0 1Apoe, in cytoplasm, is involved in cholesterol delivery for pregnenolone synthesis 1 0 1Estrogen and calcium depolymerize microtubules 1 0 2Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted 1 0 2Hypothyroidism, estrogen excess, free unsaturated fats cause increased vascular permeability and brain edema, protein leakage, and alteration of the matrix 1 0 2