Estrogen and calcium depolymerize microtubules

Negation: Estrogen and calcium do not depolymerize microtubules 0 0 0

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1 Consequence

2 Mentions

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Consequences

Argument #c25abf36 1 0 2

If it is true that...

Estrogen and calcium depolymerize microtubules 1 0 2

and

Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2

Then it must be true that...

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2

Mentions

Ray Peat/The problem of Alzheimer's disease as a clue to immortality

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Related Propositions

Toxic effects of estrogens were known by the middle of the 20th century 1 0 2 Unpleasant consequences of estrogen excess resemble some events of aging 1 0 2 Estrogen steals oxygen from mitochondria, shifting patterns of growth and adaptation 1 0 2 Estrogen's stimulation of non-mitochondrial oxygen consumption with the production of lactic acid stimulates blood vessel formation 1 0 2 The electron transfer process of the mitochondria is interrupted by the futile redox cycling catalyzed by estrogens 1 0 2 Estrogen causes cells to take up water and calcium 1 0 2 Estrogen affects our energetics and structure, and how those processes relate to aging, atrophy, cancerization, etc 1 0 2 Interactions between estrogen and unsaturated fats contribute to the aging process 1 0 2 Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age 1 0 2 Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2