If it is true that...

Estrogen and calcium depolymerize microtubules

and

Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases

Then it must be true that...

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis