Unpleasant consequences of estrogen excess resemble some events of aging
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Ray Peat/Aging, estrogen, and progesterone
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Toxic effects of estrogens were known by the middle of the 20th century 1 0 2Estrogen steals oxygen from mitochondria, shifting patterns of growth and adaptation 1 0 2Certain effects of estrogen resemble changes seen in aging such as fibrotic changes of connective tissues, accelerated accumulation of age pigment, a tendency to miscarry, or the production of degenerative changes in various organs 1 0 2The absolute levels of estrogen, or the ratio of estrogen to the antiestrogens, increases with aging in a wide variety of organisms of both sexes, including humans 1 0 2Estrogen is closely associated with the general loss of fat-free tissue with aging 1 0 2Estrogen affects our energetics and structure, and how those processes relate to aging, atrophy, cancerization, etc 1 0 2The toxicity of estrogen and unsaturated fats has been recognized for most of the twentieth century 1 0 2Interactions between estrogen and unsaturated fats contribute to the aging process 1 0 2Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age 1 0 2A vitamin A deficiency resembles stress and estrogen-toxicity aging 1 0 2