Increased cortisol and DHEA are associated with Alzheimer's disease
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Cortisol-like drugs damage the brain and other organs 1 0 2Factors known to reduce brain size at birth are also involved in the degenerating brain in old age or Alzheimer's disease 1 0 2Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age 1 0 2Even medical progestogens offer some protection against Alzheimer's disease 1 0 2Structural similarities seen in senile dementia have caused the term Alzheimer's disease to lose its original meaning 1 0 1Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs 1 0 2The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1Abnormally phosphorylated (tau) proteins are associated with Alzheimer's disease 1 0 1Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency 1 0 2