If it is true that...

Estrogen and calcium depolymerize microtubules

and

Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases

Then it must be true that...

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis

If it is true that...

Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted

and

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs