An excessive nocturnal temperature drop probably increases edema, with all of its harmful consequences
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Ray Peat/Aging, estrogen, and progesterone
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Good sleep requires fairly vigorous metabolism and a normal body temperature 1 0 2In old age, the metabolic rate is decreased and sleep becomes defective 1 0 2The disappearance of water from the blood, as it moves into the tissues during the night, makes sleep resemble a state of shock or inflammation 1 0 2Hypothermia during surgery exacerbates the edema produced by stress 1 0 2Adequate temperature improves sleep 1 0 2Melatonin increases the concentration of free fatty acids during the night 1 0 1Melatonin lowers body temperature, causes vasoconstriction in the brain, heart, and other organs, and slows reactions 1 0 2Free fatty acids and lactate impair glucose use, and promote edema, especially in the lungs 1 0 2The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1Hypothyroidism, estrogen excess, free unsaturated fats cause increased vascular permeability and brain edema, protein leakage, and alteration of the matrix 1 0 2