In old age, the metabolic rate is decreased and sleep becomes defective
Negation: In old age, the metabolic rate does not decrease and sleep does not become defective 0 0 0
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Ray Peat/Aging, estrogen, and progesterone
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Some hormones decrease with aging, while others increase 1 0 2Good sleep requires fairly vigorous metabolism and a normal body temperature 1 0 2Protein synthesis declines with aging as the metabolic rate slows 1 0 2In old age, the catabolic hormones such as cortisol are relatively dominant 1 0 2The disappearance of water from the blood, as it moves into the tissues during the night, makes sleep resemble a state of shock or inflammation 1 0 2Free fatty acids that are mobilized from storage tissues in the night and in the winter also tend to increase with aging as the ability to tolerate stress decreases 1 0 2In old age, the number of cells in the brain keeps increasing with age 1 0 2The structure of the brain goes into an "entropic" deterioration during the process of aging 1 0 2The increased lipid peroxidation of old age represents a vicious circle, in which the loss of the antioxidants and vitamin A leads to their further destruction 1 0 1The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1