In old age, the catabolic hormones such as cortisol are relatively dominant
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Ray Peat/Aging, estrogen, and progesterone
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Some hormones decrease with aging, while others increase 1 0 2Unpleasant consequences of estrogen excess resemble some events of aging 1 0 2The absolute levels of estrogen, or the ratio of estrogen to the antiestrogens, increases with aging in a wide variety of organisms of both sexes, including humans 1 0 2Estrogen is closely associated with the general loss of fat-free tissue with aging 1 0 2In old age, the metabolic rate is decreased and sleep becomes defective 1 0 2Even in young women, bone loss occurs almost entirely during the night, when cortisol is high 1 0 2The catabolic, death-inducing hormone is produced by the ovary, under the influence of the optic gland's gonadotropins 1 0 2Progesterone is both an anticatabolic hormone and an antiestrogenic hormone, protecting the functional systems from atrophy 1 0 2Progesterone is probably the most perfect antiestrogenic hormone, and therefore an anti-stress and anti-aging hormone 1 0 2Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency 1 0 2