Even in young women, bone loss occurs almost entirely during the night, when cortisol is high
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Ray Peat/Aging, estrogen, and progesterone
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Estrogen is closely associated with the general loss of fat-free tissue with aging 1 0 2In old age, the catabolic hormones such as cortisol are relatively dominant 1 0 2While estrogen is usually highest at night, progesterone is lowest during the night 1 0 2The disappearance of water from the blood, as it moves into the tissues during the night, makes sleep resemble a state of shock or inflammation 1 0 2Carbohydrate and salty foods during the night can minimize the stress reaction 1 0 2The absence of bright light can create a progesterone deficiency and leave estrogen and prolactin unopposed 1 0 2Almost any kind of stress increases the formation of melatonin 1 0 2The nocturnal/stress hormones, especially prolactin and melatonin, make the retina more sensitive to light and more easily damaged 1 0 2When pregnenolone is inadequate, cortisol is over-produced 1 0 2Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2