Free fatty acids and lactate impair glucose use, and promote edema, especially in the lungs
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Ray Peat/Altitude and Morality
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Estrogen's stimulation of non-mitochondrial oxygen consumption with the production of lactic acid stimulates blood vessel formation 1 0 2Hypothermia during surgery exacerbates the edema produced by stress 1 0 2An excessive nocturnal temperature drop probably increases edema, with all of its harmful consequences 1 0 2Melatonin increases the concentration of free fatty acids during the night 1 0 1Mitochondrial function in general is poisoned by the unsaturated fats, especially arachidonic acid and DHA 1 0 2The excess production of lactate displaces carbon dioxide from the blood, partly as a compensation for acidity 1 0 2Lactic acid triggers the defensive reactions of the organism, leading to tissue wasting from excessive glucocorticoid hormone 1 0 2Excessive supply of unsaturated fats in the diet can override some adaptive, protective regulatory processes 1 0 2Hypothyroidism, estrogen excess, free unsaturated fats cause increased vascular permeability and brain edema, protein leakage, and alteration of the matrix 1 0 2An excess of unsaturated fatty acids constitutes a massive distortion of the regulatory systems 1 0 2