Apoe, in cytoplasm, is not involved in cholesterol delivery for pregnenolone synthesis
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Cholesterol, pregnenolone, and progesterone are the main long-range defenses in the human body 1 0 2To produce pregnenolone, thyroid, vitamin A, and cholesterol have to be delivered to the mitochondria in the right proportion and sufficient quantity 1 0 2Stress is normally balanced by increased synthesis of pregnenolone, which improves the ability to cope with stress 1 0 2Lipid peroxidation damages the mitochondrias' ability to produce pregnenolone 1 0 2The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1Apoe, in cytoplasm, is involved in cholesterol delivery for pregnenolone synthesis 1 0 1Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted 1 0 2Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis 1 0 2Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency 1 0 2