It is not necessary that thyroid, vitamin A, and cholesterol be delivered to the mitochondria in the right proportion and sufficient quantity to produce pregnenolone
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Progesterone and pregnenolone, by reducing the stress reactions, should be helpful in the eye diseases of infancy and old age, as they are in the respiratory distress syndromes 1 0 1Thyroid, progesterone, magnesium, glucose, and saturated fatty acids are among the central protective elements 1 0 2Cholesterol, pregnenolone, and progesterone are the main long-range defenses in the human body 1 0 2To produce pregnenolone, thyroid, vitamin A, and cholesterol have to be delivered to the mitochondria in the right proportion and sufficient quantity 1 0 2Stress is normally balanced by increased synthesis of pregnenolone, which improves the ability to cope with stress 1 0 2Lipid peroxidation damages the mitochondrias' ability to produce pregnenolone 1 0 2When pregnenolone is inadequate, cortisol is over-produced 1 0 2Apoe, in cytoplasm, is involved in cholesterol delivery for pregnenolone synthesis 1 0 1Microtubule transport for Apo E, transthyretin, thyroid, and cholesterol for pregnenolone synthesis is disrupted when estrogen increases 1 0 2Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency 1 0 2