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The changes that occur in malnutrition and hypothyroidism affect the mitochondria in a multitude of ways

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Estrogen steals oxygen from mitochondria, shifting patterns of growth and adaptation 1 0 2Blocking electron transfer in the mitochondria lowers the energy charge of the cells 1 0 2Darkness is a stress because it impairs mitochondrial energy production 1 0 2Mitochondrial function in general is poisoned by the unsaturated fats, especially arachidonic acid and DHA 1 0 2Hyperventilation is present in hypothyroidism, and is driven by adrenalin, lactate, and free fatty acids 1 0 2Endotoxin impairs mitochondria, increases estrogen levels, causes Kupffer cells in the liver to produce more tumor necrosis factor 1 0 2Increased estrogen, nitric oxide, excitatory amino acids, cortisol, lactate, free unsaturated fatty acids, prolactin, growth hormone, histamine, serotonin, tumor necrosis factor and other pro-inflammatory cytokines and kinins, and a variety of prostaglandins and eicosanoids have been identified as anti-mitochondrial, anti-respiratory agents 1 0 2To produce pregnenolone, thyroid, vitamin A, and cholesterol have to be delivered to the mitochondria in the right proportion and sufficient quantity 1 0 2The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1Hypothyroidism, estrogen excess, free unsaturated fats cause increased vascular permeability and brain edema, protein leakage, and alteration of the matrix 1 0 2