Poor circulation and lipofuscin tend to be associated in a vicious cycle
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Collagen tends to accumulate with aging 1 0 2The low energy of cells causes them to take up water and lose their tone, allowing blood to pool in them instead of returning to the heart 1 0 2In old age, the catabolic hormones such as cortisol are relatively dominant 1 0 2Free fatty acids that are mobilized from storage tissues in the night and in the winter also tend to increase with aging as the ability to tolerate stress decreases 1 0 2Light and stress, especially with excess iron, damage the retina when the cells contain too much PUFA 1 0 2Mitochondrial function in general is poisoned by the unsaturated fats, especially arachidonic acid and DHA 1 0 2Iron accumulates to a point where its signal functions may be inappropriate during certain times, especially childhood and old age 1 0 2Endotoxin poisoning eventually tends to intervene during stress and aging, exacerbating the trend begun under the influence of other factors 1 0 2A vitamin A deficiency resembles stress and estrogen-toxicity aging 1 0 2The increased lipid peroxidation of old age represents a vicious circle, in which the loss of the antioxidants and vitamin A leads to their further destruction 1 0 1