Stimulation by estrogen doesn't produce the normal amount of carbon dioxide, leading to tissue experiencing oxygen deprivation, swelling, and cell division
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Ray Peat/Aging, estrogen, and progesterone
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Estrogen steals oxygen from mitochondria, shifting patterns of growth and adaptation 1 0 2All maladies caused by estrogen excess develop in the same way that it interferes with pregnancy, by driving the tissue to require more energy and oxygen than can be delivered to it 1 0 2Estrogen creates an oxygen deficiency, stimulates first swelling, and then collagen synthesis 1 0 2Estrogen increases the blood flow to particular organs, but apparently less than it increases their oxygen demand 1 0 2Estrogen's stimulation of non-mitochondrial oxygen consumption with the production of lactic acid stimulates blood vessel formation 1 0 2Estrogen causes cells to take up water and calcium 1 0 2Estrogen affects our energetics and structure, and how those processes relate to aging, atrophy, cancerization, etc 1 0 2Estrogen is intimately involved with the formation of the egg cell and wherever it operates, it increases both the quantity of water and the disorder of the water 1 0 2Estrogen promotes regeneration by promoting water uptake, stimulating cell division, and erasing the differentiated state to one degree or another, providing a new supply of "stem cells" 1 0 2Estrogen stimulates cell division but can also increase the rate of cell death 1 0 2