Adenosine does not have a sleep-inducing protective effect and is not a free radical scavenger
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In old age, the metabolic rate is decreased and sleep becomes defective 1 0 2Melatonin and prolactin are induced by stress 1 0 2Stress, a "respiratory defect", and free radical damage are common factors in disease and aging 1 0 2Melatonin can act as a pro-oxidant at physiologically relevant concentrations 1 0 2Melatonin increases the concentration of free fatty acids during the night 1 0 1Melatonin's ability to cause vasoconstriction means that stress makes supplemental oxygen more toxic 1 0 1Adenosine has a sleep-inducing protective effect and is a free radical scavenger 1 0 2The mitochondrial energy problem, cytochrome oxidase and its regulation; body temperature/pulse-rate cycle disturbance; lipid peroxidation; respiratory defect; altered amino acid uptake; memory impairment; dominance of the excitatory systems vs. the inhibitory adenosine/GABA/progesterone/pregnenolone system are functional and biochemical observations of Alzheimer's disease 1 0 1Free radicals and calcium cause multiple cell injuries including nerve-death 1 0 2The random production of free radicals acts as a signalling process on a strictly physiological level 1 0 2