Cells of the immune system release tumor necrosis factor and other inflammatory cytokines, and the bowel becomes more permeable, allowing endotoxin and even bacteria to enter the blood
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Ray Peat/Altitude and Morality
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The low energy of cells causes them to take up water and lose their tone, allowing blood to pool in them instead of returning to the heart 1 0 2The disappearance of water from the blood, as it moves into the tissues during the night, makes sleep resemble a state of shock or inflammation 1 0 2Estrogen increases and acts through the inflammatory mediators, serotonin and histamine, to increase vascular leakiness 1 0 2Stress, shock, inflammation, aging, and organ failure are respiratory problems in important ways 1 0 2Endotoxin impairs mitochondria, increases estrogen levels, causes Kupffer cells in the liver to produce more tumor necrosis factor 1 0 2Despite its name, tumor necrosis factor stimulates the growth and metastasis of some types of cancer 1 0 2The inflammatory factors that can promote cell growth can deplete cellular energy to the extent that the cells die from the energetic cost of the repair process, or mutate from defective repairs 1 0 2Increased estrogen, nitric oxide, excitatory amino acids, cortisol, lactate, free unsaturated fatty acids, prolactin, growth hormone, histamine, serotonin, tumor necrosis factor and other pro-inflammatory cytokines and kinins, and a variety of prostaglandins and eicosanoids have been identified as anti-mitochondrial, anti-respiratory agents 1 0 2Endotoxemia may be a factor in nerve degeneration only during adult life, but it is sometimes present during pregnancy 1 0 2Endotoxin poisoning eventually tends to intervene during stress and aging, exacerbating the trend begun under the influence of other factors 1 0 2