The loss of carbon dioxide from the lungs in the presence of high oxygen pressure does not increase the blood’s affinity for oxygen, and does not restrict its delivery to the tissues
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Supplemental oxygen without carbon dioxide causes vasoconstriction, reducing the tissues' supply of glucose as well as oxygen and damages the retina when combined with too much light 1 0 2Breathing pure oxygen lowers the oxygen content of tissues 1 0 2Breathing rarefied air or air with carbon dioxide oxygenates and energizes the tissues 1 0 1Oxygen toxicity and hyperventilation create a systemic deficiency of carbon dioxide 1 0 2Carbon dioxide deficiency makes breathing more difficult in pure oxygen, impairs the heart’s ability to work, and increases the resistance of blood vessels, impairing circulation and oxygen delivery to tissues 1 0 2In conditions that permit greater carbon dioxide retention, circulation is improved and the heart works more effectively 1 0 2When carbon dioxide production is low due to hypothyroidism, there will usually be some lactate entering the blood even at rest 1 0 2The loss of carbon dioxide from the lungs in the presence of high oxygen pressure increases the blood’s affinity for oxygen, and restricts its delivery to the tissues 1 0 2At high altitude, the slight tendency toward carbon dioxide-retention acidosis decreases the blood’s affinity for oxygen, making it more available to the tissues 1 0 2Edema in the lungs limits oxygen absorption 1 0 2