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70 inferences

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Claim

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs




Arguments

If it is true that...

Interactions between estrogen and unsaturated fats contribute to the aging process

and

Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Aspirin protects against iron toxicity, clot formation, and reduces lipid peroxidation while blocking prostaglandin formation

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Vegetable oil suppresses the thyroid, increasing estrogen

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

If rats are treated during pregnancy to increase the amount of progesterone, the offspring have bigger brains and learn more efficiently

and

Progesterone is a nerve growth factor, produced by glial cells

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Estrogen is a brain excitant, present use creates an effect on verbal fluency and other signs of awareness of the environment

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Exposure to estrogen in middle-age increases the risk of Alzheimer's disease in old age

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Free radicals and calcium cause multiple cell injuries including nerve-death

and

Estrogen is released by elevated beta-glucuronidase

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency

and

Hypothyroidism, estrogen excess, free unsaturated fats cause increased vascular permeability and brain edema, protein leakage, and alteration of the matrix

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

When progesterone is deficient, estrogen's effect is largely unopposed

and

When both thyroid and progesterone are deficient, even fat cells synthesize estrogen

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Transthyretin and apo E accumulate unused, and deposit in blood vessels, around nerves, and in cytoplasm when microtubule transport is disrupted

and

Pregnenolone and progesterone deficiency causes memory loss, destabilization of nerve cells, failure of myelin formation, and excess cortisol synthesis

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

If it is true that...

Even medical progestogens offer some protection against Alzheimer's disease

Then it must be true that...

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs


Consequences

If it is true that...

Estrogen is a brain excitant, present use creates an effect on verbal fluency and other signs of awareness of the environment

and

Alzheimer-type dementia is different from other dementias, but it overlaps with them, and with age-related and stress-related changes in other organs

Then it must be true that...

Imbalances of other steroids, including cortisol and DHEA, develop as cells compensate for pregnenolone deficiency