If it is true that...

Breathing pure oxygen lowers the oxygen content of tissues

Then it must be true that...

Carbon dioxide deficiency makes breathing more difficult in pure oxygen, impairs the heart’s ability to work, and increases the resistance of blood vessels, impairing circulation and oxygen delivery to tissues

If it is true that...

Oxygen toxicity and hyperventilation create a systemic deficiency of carbon dioxide

Then it must be true that...

Carbon dioxide deficiency makes breathing more difficult in pure oxygen, impairs the heart’s ability to work, and increases the resistance of blood vessels, impairing circulation and oxygen delivery to tissues