Melatonin cannot act as a pro-oxidant at physiologically relevant concentrations
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Retinal injury is caused by ordinary light when the eyes are sensitized by melatonin, prolactin, and polyunsaturated fats 1 0 2Melatonin and prolactin are induced by stress 1 0 2Darkness is a stress because it impairs mitochondrial energy production 1 0 2Melatonin can act as a pro-oxidant at physiologically relevant concentrations 1 0 2Melatonin increases the concentration of free fatty acids during the night 1 0 1Melatonin reduces behavioral sensitivity but increases the eyes' sensitivity to light, causing them to be injured by light that would otherwise be harmless 1 0 2The fetus accumulates a very large amount of iron and absorbs melatonin from the maternal circulation 1 0 2Melatonin's ability to cause vasoconstriction means that stress makes supplemental oxygen more toxic 1 0 1Adenosine has a sleep-inducing protective effect and is a free radical scavenger 1 0 2The random production of free radicals acts as a signalling process on a strictly physiological level 1 0 2